The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling

Abstract Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic diseases. In ovarian cancer, was identified numerous compartments, including the tumor tissue itself, upper and lower female genital tract, serum, peritoneum, intestines. Colonization linked Gram-negative bacteria with high inflammatory potential. Local inflammation probably participates initiation continuation of carcinogenesis. Furthermore, local bacterial colonies peritoneum may facilitate metastasis formation cancer. Vaginal infections (e.g. Neisseria gonorrhoeae or Chlamydia trachomatis ) increase risk developing Bacterial metabolites, produced healthy eubiome oncobiome, exert autocrine, paracrine, hormone-like effects, evidenced breast pancreas adenocarcinoma. We discuss possible involvement lipopolysaccharides, lysophosphatides tryptophan well as, short-chain fatty acids, secondary bile acids polyamines carcinogenesis applicability nutrients, antibiotics, probiotics harness microbiome support therapy. The oncobiome most likely metabolites play vital roles mediating effectiveness chemotherapy. Finally, we potential oncobiotic changes biomarkers for diagnosis microbial adjuvant agents